David Schrum

Professor, Chemistry
Chemistry

Education

B.S.  University of Wisconsin-Stevens Point, 1990

Ph.D., Purdue University, Analytical Chemistry, 1996

Advisor:  Dr. Fred E. Regnier

 

Contact

Chemistry, Hedco Hall
207
P: 909.748.8515
P: 909-748-8370
E: david_schrum@redlands.edu

Research Summaries

 

1.  Analysis and Characterization of Mesembrine type Alkaloids obtained from Sceletium tortuosum  The South African plant, Sceletium tortuosum, has been found to contain psychoactive alkaloids of the mesembrine class that alter the mental state of humans.  These alkaloids work by acting as selective serotonin reuptake inhibitors (SSRI’s), which in turn enhance the mood of the recipient.  This project will involve a method for the extraction and purification of these mesembrine compounds from the milled plant material.  To properly separate these compounds, extraction of the compounds will be confirmed using Thin Layer Chromatography, Automated Accelerated Column Chromatography and Gas Chromatography coupled with Mass Spectrometry (GC-MS).

 

2.  Electrophoretically Mediated Micro-Analysis (EMMA):  An Application of Capillary Electrophoresis.  Capillary electrophoresis (CE) is an analytical technique used to separate ions based on their electrophoretic mobility through an applied voltage.  Electrophoretically medicated microanalysis (EMMA) is and application of CE used to perform enzyme assays and to determine substrate concentrations by using Michaelis Menten kinetics and the data collected from the experiment.  One enzyme system being studied using EMMA involves lactate dehydrogenase with either lactate or pyruvate as a substrate and either NADH or NAD+ as a cofactor.  From the CE data obtained, substrate calibration curves will be prepared for use in the future with unknown substrate concentrations. 

 

3.  Separation Projects for Analytical Chemistry and Advanced Lab Utilizing the High Pressure Liquid Chromatograph Quadrupole Time of Flight Mass Spectrometer (HPLC/QTOF/MS).  Separation projects involving the separation and quantification of various active ingredients found in over the counter analgesics suitable for a one semester analytical chemistry lab or senior level advanced lab are being developed and optimized.  These projects will take advantage of our research grade HPLC/QTOF/MS and give exposure of this instrument to our undergraduate students. 

 

Teaching Experience:

 

Professor, University of Redlands                                                                 2011-present

 

Associate Professor, University of Redlands                                                 2005-2011

 

Assistant Professor, University of Redlands                                                 1999-2005

 

Adjunct Assistant Professor, Maryville College                                            1997-1998

 

 

 

Research and Professional Experience:

 

Research Professor, University of Redlands (sabbatical)                               Spring 2013

 

Visiting Research Professor, Louisiana State University (sabbatical),           2005-2006

 

  Sponsor:  Dr. S. Douglass Gilman

 

Analytical Research Associate, University of TN-Knoxville,                       Summer 2000

 

  Sponsor:  Dr. S. Douglass Gilman

 

Analytical Post-Doctoral Research Associate, Oak Ridge National              1998-1999

 

  Labs, Sponsor:  Dr. J. Michael Ramsey

 

Research Associate, Microbial Insights, Inc./ UT-Knoxville                         1996-1997

 

Quality Control Chemist, Schwarz Pharma                                                   1990-1991

 

 

 

 

Committee Assignments/ College Responsibilities:

 

College Curriculum Committee                                                                       2013-2015

 

Retention Management Working Group                                                        2010-2014

 

College of Arts and Sciences Graduation Requirements Task Force              summer 2009

 

Faculty Mentoring Committee                                                                       2008-2011

 

Chair, Chemistry Department                                                                                    2008-2011

 

Registrar Search Committee                                                                            2008-2009

 

Faculty Review Committee (chair 2007-2008)                                              2006-2008

 

Untenured Faculty Caucus, Convener                                                            2001-2003

 

Deans Advisory Committee                                                                           2001-2003

 

 

University Council                                                                                         2001-2003

 

Academic Review Board                                                                                 2000-2002

 

Chemistry Search Committees (6 tenure track)                                              1999, 2000, 2002, 2006

 

                                                                                                                        2010, 2015

 

 Grants:

 

HEDCO Foundation grant for the purchase of an HPLC/MS system           August 2010

 

Undergraduate Science Research Grant, Merck/AAAS                                  2003-2007

 

Faculty Research Grant, University of Redlands (2)                                     2001-2003

 

Hewlett Best Unfunded Grant Proposal, University of Redlands,                2000-2001

 

 

 

 

Service in Professional Organizations:

 

Chair, San Gorgonio American Chemical Society Section                              2001-2003

 

Reviewer, Journal of Chemical Education                                                      1999-present

 

 

 

 

Membership in Professional Organizations:

 

Council on Undergraduate Research

 

American Chemical Society

 

Phi Lambda Upsilon

 

Omicron Delta Kappa

 

 

 

Publications and Presentations: 

 

 

1.         D. Santeliz, J.L. Krstenanansky, D.P. Schrum, “Analysis and Characterization of

 

            Mesembrine type Alkaloids obtained from Sceletium tortuosum”, presented at the

 

            251st American Chemical Society National Meeting, San Diego, CA, March 2016.

 

2.         D. Santeliz, J.L. Krstenanansky, D.P. Schrum, “Isolating Mesembrine Alkaloids from

 

Sceletium tortuosum for Potential Dosage Studies to Determine Candidacy for

 

Inhibition of Serotonin Reuptake Pumps to Treat Depression,” presented at the

 

Southern California Conference on Undergraduate Research (SCCUR), Harvey Mudd College, November, 2015.

 

3.         L. Talbert, D.P. Schrum, “Analysis of b-Amyloid Peptides by High Performance

 

            Liquid Chromatography –Mass Spectrometry (HPLC/MS)”, presented at the Southern

 

            California Conference on Undergraduate Research (SCCUR), Whittier College,

 

            November, 2013.

 

4.         R. Picou, D.P. Schrum, G. Ku, R.A. Cerqua, I. Keterpal, S.D. Gilman, “Separation and

 

            Detection of Individual Ab Aggregates by Capillary Electrophoresis with Laser-

 

            Induced Fluorescence Detection”, Analytical Biochemistry, 425, 104-112, (2012).

 

5.         L. Talbert, D.P. Schrum, “Analysis of b-Amyloid Peptides by High Performance

 

            Liquid Chromatography –Mass Spectrometry (HPLC/MS)”, presented at the Southern

 

            California Conference on Undergraduate Research (SCCUR), CSU Channel Islands,

 

            November, 2012. 

 

 

6.         L. Hensleigh, D.P. Schrum, “Characterization of Soil Obtained from Joshua Tree

 

            National Park”, presented at the PITTCON 2011 meeting, held in Atlanta, GA,

 

March, 2011.

 

7.         M. Steele, D.P. Schrum, “Analysis of b-Amyloid Peptide Fragments Involved in

 

            Alzheimer’s Disease via Capillary Electrophoresis (CE) and High Pressure Liquid

 

            Chromatography-Mass Spectrometry (HPLC-MS)”, presented at the Southern

 

            California Conference on Undergraduate Research (SCCUR), Pepperdine University,

 

            November, 2010. 

 

8.         L. Hensleigh, D.P. Schrum, “Characterization of Soil from Joshua Tree National

 

            Park”, presented at the Southern California Conference on Undergraduate Research,

 

            (SCCUR), Pepperdine University, November 2010.

 

9.         A. Burris, D.P. Schrum, “Separation of Peptides by Open-Tubular Chromatography

 

            (OT-CEC)”, presented at the Southern California Conference on Undergraduate

 

            Research (SCCUR), California State University at Dominguez Hills, November, 2009.

 

10.       N. Grimsley, D.P. Schrum, “Analysis of Fountain Pen Inks by Capillary

 

            Electrophoresis,” presented at the Southern California Conference on Undergraduate

 

            Research, California State University, Los Angeles, November, 2007.

 

11.       L. Norris, D.P. Schrum, “Comparison of Nitrate and Phosphate Concentrations in the

 

            Leaf Tissue of Ceridium Floridum, Acacia gregigii, and Prosopis glanulosa Grown in

 

            Soil Extracted from Joshua Tree National Park,” presented at the Southern California

 

            Conference on Undergraduate Research, California State University, Los Angeles,

 

            November, 2007.

 

12.       J. Blauth, D. P. Schrum, T. Harp, H Woolverton, S. Guthrie, J. Garcia, I. Sandri,

 

“Towards Revegetation of a Disturbed Desert Wash Using Native Woody Legumes,

 

Rhizobia, and Arbuscular Mycorrhizas”, Botany & Plant Biology Joint Congress, July

 

2007.

 

13.       D.P. Schrum, J. Moses, S. D. Gilman, “Investigations of Amyloid (Ab) Fibrils

 

            Using Capillary Electrophoresis with Fluorescence Anisotropy Detection,”

 

            presented at the PITTCON 2006 meeting, held in Orlando, FL, March, 2006.

 

14.       J.R. Blauth, D.P. Schrum, “Service Learning and Field Research at the University of

 

Redlands:  Desert Restoration in Joshua Tree National Park”, CUR Quarterly, 26, December (2005) 63-65.

 

15.       A. Colclesser, D.P. Schrum, “Determination of Essential Plant Nutrient Levels in

 

            Joshua Tree National Park,” presented at the Southern California Conference on

 

            Undergraduate Research, University of California-Riverside, November, 2005

 

16.       D.L. Van Engelen, D.P. Schrum, “Incremental Development from Traditional,

 

            Expository Experiments to Guided Group Projects in the General Chemistry

 

            Laboratory,” presented at the First-Year Undergraduate Chemistry Education

 

            International Conference, held at the University of Illinois at Urbana-Champaign,

 

            May, 2005. 

 

17.       C. McClain, D.P. Schrum, “Synthesis and Characterization of Poly (Acrylic Acid)

 

            Strong Cation Exchange Ligands in Open-Tubular Capillary Electrochromatography

 

            (OT-CEC),” presented at the PITTCON 2005 meeting, held in Orlando, FL, March,

 

            2005.

 

 

 

18.       L. Lutke, H. Mitchell, J. Blauth, D.P. Schrum, “Exploring Restoration in Joshua

 

            Tree National Park using Rhizobia and Mycorrhizae,” presented at the Mojave

 

            Desert Science Symposium, held at the University of Redlands, Redlands, CA,

 

            November, 2004. 

 

19.       T. Emerick, D.P. Schrum, "Synthesis and Characterization of Poly (Acrylic Acid)

 

            Cation-Exchange Ligands for Peptide Separations in Open-Tubular Capillary

 

            Electrochromatography (OT-CEC)," presented at the PITTCON 2004 meeting,

 

            held in Chicago, IL, March, 2004. 

 

20.       H. Mitchell, J. Blauth, D.P. Schrum, “Extraction, Isolation, and Characterization of

 

            Rhizobia from Woody Legume Root Nodules,” presented at the Southern California

 

            Conference on Undergraduate Research, University of California-Irvine, November,

 

            2003.

 

21.       H. Mitchell, T. Tschann, J. Blauth, D.P. Schrum, “Re-vegetation of Disturbed Arid

 

            Lands Utilizing the Mutualistic Relationships between Woody Legumes, Rhizobia,

 

            and Mycorrhizae,” presented at the Southern California Conference on Undergraduate

 

            Research, University of California-Irvine, November, 2003.

 

22.       D.P. Schrum, “Follow the Evidence:  Forensic Science at the University of Redlands,”

 

            presented to the University of Redlands Faculty Forum, November, 2002..

 

23.       C. Kruse, D.P. Schrum, "An Investigation of Fountain Pen Inks by Capillary

 

Electrophoresis Obtained From Documents Under Various Environmental

 

Conditions," presented at the 29th Annual Meeting of the Federation of Analytical

 

Chemistry & Spectroscopy Societies (FACSS), Providence, RI, October,

 

2002.

 

24.       D.P. Schrum, D. Mueller, "Analysis and Aging Studies of Fountain Pen Inks by

 

Capillary Electrophoresis," presented at the Ninth National Conference of the

 

Council on Undergraduate Research, Connecticut College, CT, June 2002

 

25.       D. Mueller, D.P. Schrum." An Investigation of Fountain Pen Inks by Capillary

 

            Electrophoresis Obtained from Documents Under Various Conditions," presented

 

at the Southern California Undergraduate Research Conference in Chemistry and

 

Biochemistry, California State University-Northridge, April, 2002.

 

26.       D. Mueller, D.P. Schrum, "An Investigation of Fountain Pen Inks by Capillary

 

Electrophoresis Obtained from Documents Under Various Physical Conditions," presented at the PITTCON 2002 Meeting, New Orleans, LA, March 2002.

 

27.       M. Worthington, D.P. Schrum, "Analysis of Amyloid-b Peptides Using

 

Capillary Electrophoresis", presented at the PITTCON 2002 Meeting, New

 

Orleans, LA, March 2002.

 

28.       D.P. Schrum, "General Chemistry - All Laboratory, All of the Time,'' presented at

 

the Society of Western Analytical Professors meeting, UC-Riverside, Riverside,

 

CA, February, 2002.

 

29.       D.P. Schrum, D. Mueller, "Analysis of Fountain Pen Inks by Capillary

 

Electrophoresis:  A Forensic Science Project," presented at the 221st

 

American Chemical Society Meeting, San Diego, CA, April, 2001.

 

 

 30.       D.P. Schrum, M. Worthington, "Analysis of b-A4-Related Peptides, Amyloid

 

Protein Fibrils, and Their Interactions by Capillary Electrophoresis," presented at the 221st American Chemical Society Meeting, San Diego, CA, April, 2001.

 

31.       S.D. Gilman, J.L. Pittman, K.F. Schrum, D.P. Schrum, J.Batts, "Studies of

 

Electroosmotic Flow Dynamics", presented at the Pittsburgh Conference,

 

New Orleans, LA, March, 2001.

 

32.       D.P. Schrum, C.T. Culbertson, S.C. Jacobson, J.M. Ramsey, "Microchip Flow

 

Cytometry Using Electrokinetic Focusing," Anal. Chem., 71, 4173-4177, (1999).

 

33.       D.P. Schrum, C.T. Culbertson, S.C. Jacobson, J.M. Ramsey, "Microchip Flow

 

Cytometry Using Electrokinetic Focusing," presented at the 12th International

 

Symposium on High Performance Capillary Electrophoresis, Palm Springs, CA,

 

January, 1999.

 

34.       D.P. Schrum, S. Alugupalli, S.T. Kelly, D.C. White, R. Fayer, "Structural

 

Characterization of a "Signature" Phosphatidylethanalomine as the Major

 

10-Hydroxy Stearic Acid Containing Lipid of Cryptosporidium parvum

 

Oocysts," Lipids, Vol. 32, no. 7, 789-793, (1997).

 

35.       D.C. White, D.B. Ringelberg, S.J. Macnaughton, S. Alugupalli, D.P. Schrum,

 

"Signature Lipid Biomarker Analysis for Quantitative Analysis in situ of

 

Environmental Microbial Ecology," ACS Symposium Series, "Application of

 

Molecular Markers in Environmental Geochemistry," 671, 22-34, (1997), R.

 

Eagenhouse, editor.

 

36.       D.C. White, S. Alugupalli, D.P. Schrum, S.J. Macnaughton, S.T. Kelly, M.K.

 

M.K., R. Fayer, E.S. Kaneshiro, M.R. Cranfield, M.L. Williams, T.K. Graczyk,

 

"Sensitive Quantitative Detection/Identification of Infectious Cryptosporidium parvum Oocysts by Signature Lipid Biomarker Analysis;" presented at the 5th

 

International Workshop on Opportunistic Protists (IWOP) and 5th General Meeting of the European Concerted Action on Pneumocystis Research, Lille,France, September, 1997.

 

37.       D.P. Schrum, K. Smith, D.C. White, "Increased Sensitivity and Detection Limits

 

for Nitro Containing Explosives by On-column HPLC Reductions and ESI/APCI MS," presented at the 45th American Society for Mass Spectrometry Conference on Mass Spectrometry, Palm Springs, CA, June, 1997.

 

38.       D.C. White, S. Alugupalli, D.P. Schrum, S.T. Kelly, M.K. Sikka, R. Fayer,

 

E.S. Kaneshiro, "Sensitive Quantitative Detection/Identification of Infectious Cryptosporidium parvum Oocysts by Signature Lipid Biomarker Analysis;"

 

Published in the proceedings from the International Symposium on water-borne

 

Cryptosporidium, Newport Beach, CA, March, 1997.

 

*Bold faced type denotes undergraduate research students

 

 

 

 

 Workshop Participation:

 

1.        Forensic Science Workshop, sponsored by the Center for Workshops in the

 

     Chemical Sciences, National Science Foundation, held at Williams College,

 

     Williamstown, MA, June 23-28, 2002.

 

2.        Proposal Writing Institute, sponsored by the Council on Undergraduate Research,

 

     held at Juniata College, Juniata, PA, July 13-17, 2002.

 

 

 

 

Conference Sessions Organized:

 

1.        Education in Analytical Chemistry Sessions, which occurred at the 29th Annual

 

Meeting of the Federation of Analytical Chemistry & Spectroscopy Societies

 

(FACSS), Providence, RI, October, 2002. 

 

 

 

2.        Conference Program Sessions, which occurred at the Society of Western Analytical

 

           Professors (SWAP) annual meeting, Cal State University–Fullerton, Fullerton, CA,

 

     March, 2003.